By G.O. Evans
Hematology facts from in vivo toxicology reports continues to be considered one of the main predictive measures for human threat, because the related measurements made in pre-clinical toxicology stories might be made in early scientific trials.
Covering the 3 major blood cellphone varieties – erythrocytes, leukocytes and thrombocytes, this paintings is designed to explain themes for brand spanking new entrants to the fields of laboratory animal hematology and toxicology, specially these subject matters the place the foundations for human hematology don't continually observe. a whole bankruptcy is dedicated to immunotoxicology, a systematic self-discipline that's heavily aligned with hematology.
The textual content additionally addresses pre-analytical and analytical variables that impact animal reviews, as those play a much more vital half whilst analyzing info unlike people the place lots of those variables should be good managed or have much less physiological influence. info has been collated from released papers, textbooks and unpublished info: Readers are supplied with key references to inspire extra research
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Additional info for Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers
1993. Development and application of in vitro models of hematopoiesis to drug development. Toxicol. Pathol. 21:231–40. Dexter, T. , Allen, T. , and Lajtha, L. G. 1977. Conditions controlling the proliferation of haematopoietic stem cells in vitro. J. Cell. Physiol. 91:335–44. Dexter, T. , and Spooner, E. 1987. Growth and differentiation in the haemopoietic system. Ann. Rev. Cell. Biol. 3:423–41. indb 21 6/24/08 5:26:43 AM 22 Animal Hematotoxicology Irons, R. , Le, A. , Som, D. , and Stillman, W.
1993; Parchment, 1998). , 2003). The time period required for the development of erythroid colony-forming units (CFU-E), blast-forming units (B-CFU), and granulocyte/monocyte colony-forming units (CFU-GM) varies between species. , 1993). In vitro screening methods using human umbilical cord blood, placental blood, or umbilical vein endothelial cells (HUVECs) have also been used to screen for hemotoxicants. There is an advantage in using different cell assays for different toxic effects. Progenitor and precursors cells are suitable for acute toxic effects, stem cells for chronic toxicity, and stromal cells or microenvironmental assays for stromal effects.
106:121–36. Irons, E. , ed. 1985. Toxicology of the blood and bone marrow. New York: Raven Press. Lajtha, L. G. 1970. Kinetics of haemopoiesis. Br. J. Radiol. 44:519. Schwarzmeier, J. D. 1996. The role of cytokines in haematopoiesis. Eur. J. Haematol. ):69–74. Testa, N. , eds. 1993. Haematopoiesis: A practical approach. Oxford: IRL Press. Weiss, L. P. 1995. The structure of hematopoietic tissues. In Blood: Principles and practice of hematology, ed. R. I. Handin, S. E. Lus, and T. P. Stossel. Philadelphia: JB Lippincott.
Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers by G.O. Evans