An Introduction to Male Reproductive Medicine - download pdf or read online

By Craig Niederberger

ISBN-10: 0521173027

ISBN-13: 9780521173025

An advent to Male Reproductive drugs is written in particular for readers looking access into this fast-moving, complicated distinctiveness with an effective figuring out of the topic. the 1st chapters disguise the anatomy and body structure, medical review, surgical procedure, medication, genetics and laboratory checking out focused on the present overview and therapy of the infertile male, and the ultimate bankruptcy describes the interplay of the sphere with woman reproductive medication. through the publication, references are at once made to the fourth variation of the most important textual content within the uniqueness, Infertility within the Male, edited through Larry Lipshultz, Stuart Howards and Craig Niederberger, permitting readers to extend their realizing of particular parts the place wanted. every one bankruptcy is written by way of a well-renowned specialist in a simple to persist with, casual variety, making the textual content excellent for college students, citizens and basic physicians who're trying to raise their normal wisdom of the sector.

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Extra info for An Introduction to Male Reproductive Medicine

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Testicular torsion may have resulted in orchiectomy, or a twisted testis may have been untwisted after a time and then surgically fixed in the scrotum, leading to partial or complete necrosis. Asking about when a boy’s voice changed, and when he developed facial, axillary, and genital hair, lends insight into whether puberty was delayed in the presence of an endocrine condition. A chapter in this book is devoted entirely to genetics. Common questions to ask of the family history are whether any blood relative had or has cystic fibrosis, or had difficulty impregnating or conceiving.

However, the free and bioavailable testosterone fractions would also have enhanced access to sites of testosterone inactivation by degradative metabolism that terminate androgen action; therefore, these fractions may alternatively be considered the most evanescent and least active. Furthermore, empirical evidence indicates that, rather than being biologically inert, SHBG participates actively in cellular testosterone uptake via specific SHBG membrane receptors. Mechanism of androgen action Androgen action results from ligand binding to AR and translocation of the bound, dimerized receptor–ligand complex to the nucleus, where it directs androgen-regulated gene transcription via interaction with androgen response elements.

Specific activation of transcription at discrete sites on the chromatin. AR is expressed in Sertoli, Leydig, peritubular myoid, and vascular smooth muscle cells, and on germ cells during the early stages of spermatogenesis. The male reproductive ductal system Epididymis On the basis of histologic and ultrastructural differences, the epididymis can be grossly divided into three regions including the caput (head), corpus (body), and cauda (tail) epididymidis. Each epididymal region carries out distinctive functions with the caput and corpus carrying out early and late sperm maturational events, respectively, while the cauda region primarily serves as a storage site for functionally mature spermatozoa.

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An Introduction to Male Reproductive Medicine by Craig Niederberger

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