Read e-book online ADAMTS13: Biology and Disease PDF

By George M. Rodgers

ISBN-10: 3319087169

ISBN-13: 9783319087160

ISBN-10: 3319087177

ISBN-13: 9783319087177

This finished quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and scientific study. The 9 authoritative chapters commence with a historic point of view through exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising study issues for ADAMTS13 are coated, together with its strength position in angiogenesis and different features of mobilephone biology. extra themes contain laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on similar thrombotic microangiopathic (TMA) problems examines the variations among TMAs linked to ADAMTS13 deficiency and people no longer linked to ADAMTS13 deficiency. a last bankruptcy studies the initial details on rising elements of ADAMTS13, equivalent to the prestige of recombinant ADAMTS13 items and their power utility.

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and sickness is an important source for scientific hematologists, transfusion medication physicians, and researchers drawn to hemostasis, vascular biology, biochemistry, and metalloproteases.

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2006;281(18):12485–94. 38. Longpre JM, Leduc R. Identification of prodomain determinants involved in ADAMTS-1 biosynthesis. J Biol Chem. 2004;279(32):33237–45. 39. Longpre JM, McCulloch DR, Koo BH, Alexander JP, Apte SS, Leduc R. Characterization of proADAMTS5 processing by proprotein convertases. Int J Biochem Cell Biol. 2009; 41(5):1116–26. pii: S1357-2725(08)00414-7. 008. Epub 2008/11/11. 40. Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AM. ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.

2008;14(2):298–311. 70. Hanset R, Lapiere CM. Inheritance of dermatosparaxis in the calf. A genetic defect of connective tissues. J Hered. 1974;65(6):356–8. 71. Lapiere CM, Lenaers A, Kohn LD. Procollagen peptidase: an enzyme excising the coordination peptides of procollagen. Proc Natl Acad Sci U S A. 1971;68(12):3054–8. 72. Nusgens BV, Verellen-Dumoulin C, Hermanns-Le T, De Paepe A, Nuytinck L, Pierard GE, Lapiere CM. Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis.

15. Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem. 2004;279(17): 17554–61. 16. Kashiwagi M, Tortorella M, Nagase H, Brew K. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem. 2001;276(16):12501–4. 17. Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, Nagase H.

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ADAMTS13: Biology and Disease by George M. Rodgers


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