Read e-book online ADAMTS13: Biology and Disease PDF

By George M. Rodgers

ISBN-10: 3319087169

ISBN-13: 9783319087160

ISBN-10: 3319087177

ISBN-13: 9783319087177

This finished quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and scientific study. The 9 authoritative chapters commence with a historic point of view through exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising study issues for ADAMTS13 are coated, together with its strength position in angiogenesis and different features of mobilephone biology. extra themes contain laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on similar thrombotic microangiopathic (TMA) problems examines the variations among TMAs linked to ADAMTS13 deficiency and people no longer linked to ADAMTS13 deficiency. a last bankruptcy studies the initial details on rising elements of ADAMTS13, equivalent to the prestige of recombinant ADAMTS13 items and their power utility.

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and sickness is an important source for scientific hematologists, transfusion medication physicians, and researchers drawn to hemostasis, vascular biology, biochemistry, and metalloproteases.

Show description

Read or Download ADAMTS13: Biology and Disease PDF

Similar hematology books

Get Schalm's Veterinary Hematology PDF

The long-awaited 6th version of Schalm’s Veterinary Hematology has been revised and reorganized to extend accessibility and cohesiveness of the textual content. themes are grouped inside demonstrated disciplines in hematology, and descriptions at the moment are integrated before everything of every bankruptcy. The publication good points new sections on Hematotoxicity and quality controls and Laboratory ideas, and comprises elevated sections on Laboratory Animal Hematology, Species particular Hematology, and Hematologic Neoplasia.

Bohuslav Dobias, Hansjoachim Stechemesser's Coagulation and Flocculation, Second Edition (Surfactant PDF

First released in 1993, Coagulation and Flocculation is a realistic reference for the researchers within the box of the stabilization and destabilization of good good dispersions. by way of omitting chapters that remained unchanged from the 1st version, the editors of this moment version thoroughly replace, rewrite, and extend upon all chapters to mirror a decade of the most recent advances in either theoretical and alertness features of the sector.

Treatment of acute leukemias : new directions for clinical by Ching-Hon Pui PDF

Pui (U. of Tennessee overall healthiness technology middle) provides forty two papers which are dedicated to opting for and discussing pivotal matters that will be resolved via higher purposes of present tools of leukemia administration, instead of anticipating laboratory discoveries to force swap. Chapters examine

Additional info for ADAMTS13: Biology and Disease

Example text

2006;281(18):12485–94. 38. Longpre JM, Leduc R. Identification of prodomain determinants involved in ADAMTS-1 biosynthesis. J Biol Chem. 2004;279(32):33237–45. 39. Longpre JM, McCulloch DR, Koo BH, Alexander JP, Apte SS, Leduc R. Characterization of proADAMTS5 processing by proprotein convertases. Int J Biochem Cell Biol. 2009; 41(5):1116–26. pii: S1357-2725(08)00414-7. 008. Epub 2008/11/11. 40. Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AM. ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.

2008;14(2):298–311. 70. Hanset R, Lapiere CM. Inheritance of dermatosparaxis in the calf. A genetic defect of connective tissues. J Hered. 1974;65(6):356–8. 71. Lapiere CM, Lenaers A, Kohn LD. Procollagen peptidase: an enzyme excising the coordination peptides of procollagen. Proc Natl Acad Sci U S A. 1971;68(12):3054–8. 72. Nusgens BV, Verellen-Dumoulin C, Hermanns-Le T, De Paepe A, Nuytinck L, Pierard GE, Lapiere CM. Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis.

15. Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem. 2004;279(17): 17554–61. 16. Kashiwagi M, Tortorella M, Nagase H, Brew K. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem. 2001;276(16):12501–4. 17. Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, Nagase H.

Download PDF sample

ADAMTS13: Biology and Disease by George M. Rodgers

by Steven

Rated 4.79 of 5 – based on 6 votes