Acute Myelogenous Leukemia (Contemporary Hematology) - download pdf or read online

By Judith E. Karp

ISBN-10: 1588296210

ISBN-13: 9781588296214

This is a well timed compilation of latest options within the molecular pathogenesis and molecular treatment of acute myelogenous leukemia (AML). the point of interest is on chosen severe molecular determinants of AML pathogenesis and pathophysiology and the exploitation of those elements through diversified healing brokers and modalities. there's an emphasis all through at the bidirectional move of information among the medical and laboratory arenas.

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120. Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematological malignancies. Blood 2001;97:2434-2439. 121. Fiedler W, Serve H, Dohner H, et al. A phase I study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 2005;105(3):986-993. 122. O'Farrell AM, Foran IM, Fiedler W, et al. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients.

Marcucci G, Byrd JC, Dai G, et al. Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood 2003; 101:425-432. 147. Marcucci G, Stock W, Dai G, et al. G3139, a BCL-2 antisense oligo-nucleotide, in AML. Ann. Hematol 2004;83 (suppl l):S93-94. 148. Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell 1994;79:13-21. 149. Almond JB, Cohen GM. The proteasome: a novel target for cancer chemotherapy.

Blood 1999;94:383a. 175. Solary E, Drenou B, Campos L, et al. Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia. Blood 2003;102:1202-1210. 176. Van der Holt B, Lowenberg B, Burnett AK, et al. The value of the MDRI reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDRI status at diagnosis. Blood 2005;106(8): 2646-2654.

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Acute Myelogenous Leukemia (Contemporary Hematology) by Judith E. Karp

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