New PDF release: ABC of Clinical Haematology

By Drew Provan

ISBN-10: 0727916769

ISBN-13: 9780727916761

Overlaying hematological elements of components akin to pathology, molecular technological know-how, melanoma, and basic medication, this consultant turns out to be useful as a reference for normal perform and health center employees, hematologists and trainees in hematology. This moment variation displays advances within the realizing of the molecular biology of affliction because the first version used to be released in 1998. Provan teaches within the division of Hematology at Queen Mary's college of medication and Dentistry.

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Sample text

Increased platelet consumption may be due to immune or non-immune mechanisms. Idiopathic thrombocytopenic purpura (ITP) is a relatively common disorder and is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia. In adults it often presents insidiously, most frequently in women aged 15-50 years and can be associated with other autoimmune diseases, in particular systemic lupus erythematosus or the primary antiphospholipid syndrome. In children the onset is more acute and often follows a viral infection.

7 Red cell fragmentation in patient who presented with confusion and lethargy in whom thrombotic thrombocytopenic purpura was diagnosed. 5 Thrombocytosis • Essential (primary) thrombocytosis • Reactive (secondary) thrombocytosis Infection Malignant disease Acute and chronic inflammatory diseases Pregnancy After splenectomy Iron deficiency Haemorrhage Platelet disorders History and examination of patients Abnormal bleeding associated with thrombocytopenia or abnormal platelet function is characterised by spontaneous skin purpura and ecchymoses, mucous membrane bleeding and protracted bleeding after trauma.

Some patients will self-exclude on personal, age or health grounds. Others may be suitable for BMT but not have an appropriate donor. This problem is likely to worsen as family size reduces and volunteer healthy donors are harder to attract. 3 Survival with acute leukaemia Type At 5 years Childhood acute lymphoblastic leukaemia Adult acute lymphoblastic leukaemia Acute myeloid leukaemia, aged Ͻ60 years Acute myeloid leukaemia, aged Ͼ60 years 65-75% 20-45% 35-40% 10% The acute leukaemias Novel developments The majority of new presentations with acute leukaemia occur in the older population.

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ABC of Clinical Haematology by Drew Provan


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